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Pazopanib(GW-786034)
Description of:Pazopanib(GW-786034)
Pazopanib (GW-786034) is a second-generation multitargeted tyrosine kinase inhibitor against VEGFR-1, 2 and...
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NVP-AEW541
Description of:NVP-AEW541
NVP-AEW541 is an IGF-IR inhibitor with an IC50 of median 3.6 μM.
Theoretical analysis:NVP-AEW541
M...
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BMS-536924
Description of:BMS-536924
BMS-536924 is a small molecule ATP-competitive IGF-IR kinase inhibitor with with an IC50 of 80 nM.
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NVP-ADW742
Description of:NVP-ADW742
NVP-ADW742 is an ATP-competitive inhibitor that inhibits IGF-IR autophosphorylation with a cellular IC50 of 0.1 to 0....
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BMS-754807
Description of:BMS-754807
BMS-754807 inhibits the phosphorylation of IGF-1R (IC50 = 13nM) and the downstream targets Akt (IC50 = 22nM) and MAPK...
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Linsitinib(OSI906)
Description of:Linsitinib(OSI906)
Linsitinib(OSI906) is a potential first-in-class selective small molecule, dual kinase inhibitor of both...
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GSK1904529A
Description of:GSK1904529A
GSK1904529A selectively inhibits IGF-IR and IR with IC50s of 27 and 25 nmol/L, respectively.IC50s for GSK1904529A in...
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CUDC101
Description of:CUDC101
CUDC-101 is a drug which displays potent in vitro inhibitory activity against HDAC, EGFR, and HER2 with an IC50 of 4.4, ...
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Canertinib(CI-1033)
Description of:Canertinib(CI-1033)
CI-1033 effectively inhibits the growth of esophageal squamous cell carcinoma which co-expresses both EGFR a...
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Canertinib dihydrochloride
Description of:Canertinib dihydrochloride
An orally bioavailable tyrosine kinase inhibitor, targeting EGFR, irreversibly inhibiting their...
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