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Antibody-drug Conjugate/ADC Related
HDAC6
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Product name : SB939
Item : CR1133
CAS : 929016-96-6
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| Details: |
Description of:SB939
SB939 is a new hydroxamic acid based histone deacetylase inhibitor with IC50 of 0.48 μM for HCT-116 colon cancer cell line and 70 nM for HL-60 acute myeloid leukemia cell line. In vitro, SB939 inhibits class I, II, and IV HDACs, with no effects on other zinc binding enzymes, and shows significant antiproliferative activity against a wide variety of tumor cell lines. It has very favorable pharmacokinetic properties after oral dosing in mice, with >4-fold increased bioavailability and 3.3-fold increased half-life over suberoylanilide hydroxamic acid (SAHA). In contrast to SAHA, SB939 accumulates in tumor tissue and induces a sustained inhibition of histone acetylation in tumor tissue. Theoretical analysis:SB939 M.Wt: 358.48 Formula: C20H30N4O2 Solubility: Unknown Purity: >99% Storage: at -20 CAS No: 929016-96-6 Availability and price:SB939 Pakage：10mg/25mg/100mg/250mg/500mg/1g/5g Stock : in stock We offer significant discount for larger quantity order. For quotation, question, and order, please send email to : sales@chemrenpharm.com Quality control data: Quality Control by H-NMR,C-NMR,LC-MS,HPLC. Product will be shipped with supporting analytical data. Fast delivery about 4-5 working days |
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