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Antibody-drug Conjugate/ADC Related
MAP4K
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Product name : VX745
Item : CR1069
CAS : 209410-46-8
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| Details: |
Description of:VX745
In vitro, VX-745 was selective for p38 MAPK compared to a large panel of kinases (IC50≥20µM). VX-745 selectively inhibited p38α MAPK (IC50=10 nM), p38β MAPK (IC50 =220 nM) [368149], but not p38γ MAPK (IC50≥20 µM). In addition, cell data for VX-745 provided IC50 values of 56 and 52 nM for IL-1β and TNFα, respectively, and VX-745 blocked IL-6 and IL-8 production induced by IL-1 and TNFα. In a human whole blood assay, IC50 values were 152 and 177 nM for IL-1β and TNFα inhibition, respectively. Theoretical analysis:VX745 M.Wt:436.26 Formula:C19H9Cl2F2N3OS Solubility:Soluble to 100 mM in DMSO Purity:>98% Storage:Store at -20°C CAS No: 209410-46-8 Availability and price:VX745 Pakage：250mg/500mg/1g/5g We offer significant discount for larger quantity order. For quotation, question, and order, please send email to : sales@chemrenpharm.com Quality control data: Quality Control by H-NMR,C-NMR,LC-MS,HPLC. Product will be shipped with supporting analytical data. Fast delivery about 4-5 working days |
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