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Product name : Ibutamoren Mesylate
Item : CR2020
CAS : 159752-10-0
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Biological Activity of Ibutamoren Mesylate

Ibutamoren mesylate (MK-0677) is an orally active nonpeptide growth hormone (GH) secretagogue.
IC50 Value:
Target: GHSR
Ibutamoren mesylate (MK-0677)  stimulates GH release through a pituitary and hypothalamic receptor that is different from the GH-releasing hormone receptor. MK-677is a drug which acts as a potent, orally active growth hormone secretagogue, mimicking the GH stimulating action of the endogenous hormone ghrelin. It has been demonstrated to increase the release of, and produces sustained increases in plasma levels of several hormones including growth hormone and IGF-1, but without affecting cortisol levels. It is currently under development as a potential treatment for reduced levels of these hormones, such as in growth hormone deficient children or elderly adults, and human studies have shown it to increase both muscle mass and bone mineral density, making it a promising therapy for the treatment of frailty in the elderly. Ibutamoren mesylate (MK-0677)  also alters metabolism of body fat and so may have application in the treatment of obesity.

Chemical Information

M.Wt 624.77 Storage Please store the product under the recommended conditions in the Certificate of Analysis.
Formula C28H40N4O8S2
CAS No 159752-10-0
Solvent & Solubility

10 mM in DMSO

Preparing Stock Solutions

1 mg 5 mg 10 mg
1 mM 1.6006 mL 8.0029 mL 16.0059 mL
5 mM 0.3201 mL 1.6006 mL 3.2012 mL
10 mM 0.1601 mL 0.8003 mL 1.6006 mL

Clinical Information of Ibutamoren Mesylate

Product Name Sponsor Only Condition Start Date End Date Phase Last Change Date
Ibutamoren Mesylate University of Virginia   31-JUL-98 30-JUN-04 Phase 2 28-DEC-11
Merck & Co Inc Bone injury 31-JUL-05   Phase 2 24-MAY-13
Merck & Co Inc Alzheimers disease 30-NOV-03   Phase 2 26-DEC-11
Oregon Health Sciences University Fibromyalgia 31-JUL-05 30-APR-08 Phase 2 07-AUG-12

References on Ibutamoren Mesylate

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