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CAL101(Acalisib)
Description of:CAL101
CAL-101 blocked constitutive phosphatidylinositol-3-kinase signaling, resulting in decreased phosphorylation of Akt and o...
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A66
Description of:A66
A66 is a highly specific and selective p110α inhibitor with IC50 of 32,30 and 43 nM for p110α, p110α...
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PIK-75
Description of:PIK-75
Cell-based assays revealed that PIK-75 potently and dose dependently inhibits in vitro and in vivo production of TNF-alph...
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Pictilisib(GDC-0941)
Description of:GDC-0941
GDC-0941 was much less potent on mTOR and DNA-PK. Importantly, the activity of GDC-0941 against the panel of human tumo...
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BEZ235(NVP-BEZ235)
Description of:BEZ235(NVP-BEZ235)
NVP-BEZ235 inhibited the activation of the downstream effectors Akt, S6 ribosomal protein, and 4EBP1 in breas...
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ZSTK474
Description of:ZSTK474
ZSTK474 has strong antitumor activities against human cancer xenografts (A549, PC-3 and WiDr) when administered orally t...
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NVP-BKM120(Buparlisib)
Description of:NVP-BKM120
NVP-BKM120 is a potent, selective, orally bioavailable Class I PI3 Kinase Inhibitor for treating Cancer.
The...
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BAG956(NVP-BAG956)
Description of:BAG956(NVP-BAG956)
NVP-BAG956(BAG 956) is a potent, ATP-competitive and selective dual PI3K and PDK1 inhibitor in vitro and in v...
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BX912
Description of:BX912
BX-912 is a inhibitor of 3-Phosphoinositide-dependent Kinase-1 (PDK1).
Theoretical analysis:
M.Wt: 4...
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WYE125132
Description of:WYE 125132
WYE-132 inhibited mTORC1 and mTORC2 in diverse cancer models in vitro and in vivo. Importantly,consistent with geneti...
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Chromatin/Epigenetics
AMPK
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