Chemren Bio-Engineering Co., Ltd.

PKI-402

PKI-402

Description of:PKI-402
PKI-402 gave rise to in vitro growth inhibition of human tumor cell lines derived from breast, brain (glioma), pancreas,...
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XL147

XL147

Description of:XL147
XL147 reversibly binds to class 1 PI3Ks in an ATP-competitive manner, inhibiting the production of PIP3 and activation of ...
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PIK90

PIK90

Description of:PIK90
PIK-90 is a PI3K inhibitor,IC50=11, 350, 18, and 58 for p110 α, β, γ and δ isoforms.
Theor...
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XL765

XL765

Description of:XL765
XL765 is a mixed mTOR/PI3k inhibitor with IC50 of 157, 39, 113, 9 and 43 nM for mTOR, p110α, β, γ and &de...
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CAL101

CAL101

Description of:CAL101
CAL-101 blocked constitutive phosphatidylinositol-3-kinase signaling, resulting in decreased phosphorylation of Akt and o...
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A66

A66

 Description of:A66
A66 is a highly specific and selective p110α inhibitor with IC50 of 32,30 and 43 nM for p110α, p110α...
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PIK-75

PIK-75

Description of:PIK-75
Cell-based assays revealed that PIK-75 potently and dose dependently inhibits in vitro and in vivo production of TNF-alph...
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GDC-0941

GDC-0941

Description of:GDC-0941
GDC-0941 was much less potent on mTOR and DNA-PK. Importantly, the activity of GDC-0941 against the panel of human tumo...
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BEZ235(NVP-BEZ235)

BEZ235(NVP-BEZ235)

Description of:BEZ235(NVP-BEZ235)
NVP-BEZ235 inhibited the activation of the downstream effectors Akt, S6 ribosomal protein, and 4EBP1 in breas...
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ZSTK474

ZSTK474

Description of:ZSTK474
ZSTK474 has strong antitumor activities against human cancer xenografts (A549, PC-3 and WiDr) when administered orally t...
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