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AZD8055
Description of:AZD8055
In vitro, AZD8055 potently inhibits proliferation and induces autophagy in H838 and A549 cells.In vivo, AZD8055 induces ...
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OSI-027
Description of:OSI-027
OSI-027 binds to and inhibits both the raptor-mTOR (TOR complex 1 or TORC1) and the rictor-mTOR (TOR complex 2 or TORC2)...
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PP242
Description of:PP242
PP242 inhibits other PI 3-Kinases only at much higher concentrations. PP242, but not rapamycin, causes death of mouse and ...
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WYE-354
Description of:WYE-354
WYE-354,a cell-permeable pyrazolopyrimidine compound,is a potent and ATP competitive inhibitor of mTOR (IC50 = 5 nM), wi...
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Torin 2
Description of:Torin 2
Torin2 is potent and selective mTOR inhibitor (IC50 = 2.1 nM). Torin2 displays 800-fold cellular selectivity for mTOR ov...
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Torin1
Description of:Torin1
Torin1 is potent and selective mTOR inhibitor (IC50 = 2 - 10 nM for mTORC1 and mTORC2). Torin1 displays 200-fold selectiv...
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GDC-0980(Apitolisib)
Description of:GDC-0980(RG7422)
GDC-0980 (RG7422) prevents mTOR with a Ki of 17 nM. GDC-0980 (RG7422) is highly selective versus a large ...
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NVP-BGT226
Description of:NVP-BGT226
NVP-BGT226 is a novel PI3K/mTOR dual inhibitor.
Theoretical analysis:NVP-BGT226
M.Wt: 650.61
F...
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KU 0063794
Description of:KU 0063794
KU-0063794 displays no activity at PI 3-kinase or 76 other kinases tested. Inhibits activation and hydrophobic motif ...
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Deforolimus(MK-8669)
Description of:Deforolimus(MK-8669)
Deforolimus (Ridaforolimus) is a small-molecule inhibitor of mTOR.
Theoretical analysis:Deforoli...
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