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SNS-314
Description of:SNS-314
SNS-314 is inhibitor of Aurora kinases A(IC50=9.0nM), B(IC50=31nM), and C(IC50=3.4nM).
Theoretical analysis:SNS...
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Hesperadin
Description of:Hesperadin
Hesperadin causes this phenotype by inhibiting the function of the mitotic kinase Aurora B. Hesperadin is a human Aur...
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GSK1070916
Description of:GSK1070916
GSK1070916 displays dose-dependent inhibition of phosphorylation of an Aurora B–specific substrate in mice and ...
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JNJ-7706621
Description of:JNJ-7706621
JNJ-7706621 slowed the growth of cells and at higher concentrations induced cytotoxicity. Inhibition of CDK1 kinase ...
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MLN8054
Description of:MLN8054
Human tumor cells treated with MLN8054 show a high incidence of abnormal mitotic spindles, often with unseparated centro...
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PHA-680632
Description of:PHA-680632
PHA-680632 is active on a wide range of cancer cell lines and shows significant tumor growth inhibition in different ...
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MK-04579(Tozasertib)
Description of:Tozasertib
Tozasertib inhibits Aurorakinases A,B and C with Ki values of 0.6, 18 and 4.6 nM, resp.
Theoretical analysis...
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ZM-447439
Description of:ZM-447439
ZM-447439 is a novel, selective ATP-competitive inhibitor of Aurora B kinase in vitro. (IC50 values are 50, 250 ...
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Barasertib(AZD1152-HQPA)
Description of:Barasertib
Barasertib is a highly potent and selective inhibitor of Aurora B (Ki, 0.36 nM) compared with Aurora A (Ki, 1,369 nM)...
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Chromatin/Epigenetics
Aurora B
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