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产品 > Receptor Tyrosine Kinases > FGFR > Danusertib(PHA-739358)
产品名称 : Danusertib(PHA-739358)
型号 : CR1198
CAS : 827318-97-8
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产品详细:

Description of:Danusertib(PHA-739358)
PHA-739358 is a pyrrolo-pyrazole, which inhibits Aurora kinases in a biochemical assay with IC50s of 13, 79, and 61 nmol/L for Aurora A, B, and C, respectively. High activity was also observed against other kinases: Ret, Trk-A, and Abl (~2-fold higher IC50 compared with Aurora A), FGFR-1(4-fold higher IC50 compared with Aurora A).Several tumor cell lines (including colon, breast, prostate, lung, and ovary) were exposed to PHA-739358 and cell IC50 was in the range of 28 nmol/L (A2780) up to 300 nmol/L (U2OS).The compound has good PK properties and a strong antitumor activity observed in a broad range of in vivo tumor models with minor and transient toxicity signs. 


Theoretical analysis:Danusertib(PHA-739358)
M.Wt: 474.55
Formula: C26H30N6O3
Solubility: Soluble in DMSO
Purity: >99%
Storage: -20C 2 years
CAS No: 827318-97-8

Availability and price:Danusertib(PHA-739358)
Pakage:25mg/50mg/100mg/250mg/500mg/1g/5g
Stock : in stock
We offer significant discount for larger quantity order.
For quotation, question, and order, please send email to :
orders@chemrenblock.com

Quality control data:
Quality Control by H-NMR,C-NMR,LC-MS,HPLC.
Product will be shipped with supporting analytical data.
Fast delivery about 4-5 working days

 


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