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IC-87114
Description of:IC-87114
IC-87114 was the first isoform-selective PI3K inhibitor. p110δ(IC50 = 0.13 µM) vs. p110α(IC50 = 200 &...
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TG100-115
Description of:TG100-115
TG100-115 is applied to anti-inflammatory therapy for respiratory diseases such as asthma and chronic obstructive pulm...
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TGX221
Description of:TGX221
TGX-221 interfered with shear stress-induced PtdIns(3,4)P2 production and integrin αIIbβ3-mediated adhesion in...
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PI103
Description of:PI103
PI-103(CAS:371935-74-9) is inhibitor of DNA-PK, PI 3-kinase (p110α) and mTOR. (IC50 values are 2, 8, 20, 26, 48, 83,...
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GSK2126458|Omipalisib
Description of:GSK2126458|Omipalisib
GSK2126458 (CAS:1086062-66-9) is a highly potent PI3K and mTOR inhibitor with an app Ki of 19 pM for PI3K....
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AZD6482
Description of:AZD6482
AZD 6482(CAS:1173900-33-8) is a PI3Kβ inhibitor (IC50=0.021μM) used in antithrombotic therapy. This agent target...
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pp121
Description of:pp121
PP121 is dual inhibitor of receptor tyrosine kinases (RTKs) (IC50 < 0.02 μM for Abl, Src, VEGFR-2 and PDGFR) and PI ...
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PKI587(Gedatolisib)
Description of:PKI587
PF-05212384 (PKI-587) is a potent and selective dual PI3K/mTOR inhibitor in clinical trials.
Theoretical analysi...
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PKI-402
Description of:PKI-402
PKI-402 gave rise to in vitro growth inhibition of human tumor cell lines derived from breast, brain (glioma), pancreas,...
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XL147
Description of:XL147
XL147 reversibly binds to class 1 PI3Ks in an ATP-competitive manner, inhibiting the production of PIP3 and activation of ...
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Chromatin/Epigenetics
AMPK
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