常州市存仁生物工程有限公司

Serdemetan(JNJ 26854165)

Serdemetan(JNJ 26854165)

Description of:Serdemetan
Serdemetan(JNJ 26854165) is an orally bioavailable, first-in-class small-molecule HDM2 antagonist with potential anti...
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Nutlin-3

Nutlin-3

Description of:Nutlin-3
Nutlin-3 is a MDM-2 antagonist with an IC50 of 90 nM. It induces the expression of p53-regulated genes and exhibits pot...
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Nutlin-3a (chiral)

Nutlin-3a (chiral)

Description of:Nutlin-3a (chiral)
Nutlin-3 is MDM2 antagonist. Nutlin-3 inhibits the MDM2-p53 interaction (IC50 = 0.09 μM) and activates p53...
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ABT-737/ABT737

ABT-737/ABT737

Description of:ABT-737
ABT-737 induces Bax conformational change but fails to activate Bak or trigger Bax translocation. Coadministration of ro...
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TW-37

TW-37

Description of:TW-37
TW-37 is Bcl-2 inhibitor (Ki values are 0.29 μM and 1.11 μM for Bcl-2 and Bcl-XL respectively). TW-37 inhibits the a...
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HA14-1

HA14-1

Description of:HA14-1
HA14-1 is cell-permeable inhibitor of Bcl-2 protein (IC50 ~ 9 μM). HA14-1 acts by binding to the surface pocket. Disru...
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Obatoclax

Obatoclax

Description of:Obatoclax
Obatoclax is Bcl-2 homology domain-3 (BH3) mimetic,antagonize all antiapoptotic Bcl-2 family proteins (average IC50, 3...
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Navitoclax(ABT-263)

Navitoclax(ABT-263)

Biological Activity:Navitoclax(ABT-263)
Navitoclax(ABT263) is a small molecule that is designed to restore apoptosis, also known as programmed ...
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