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Antibody-drug Conjugate/ADC Related
Ferroptosis
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Description of:YM155
YM155, a novel small molecule survivin inhibitor, suppressed expression of survivin and induced apoptosis in PC-3 and PPC-1 human HRPC cell lines at 10 nmol/L. In a s.c.xenogr afted PC-3 tumor model in mice, 3-day continuous infusions of YM155 at 3 to 10 mg/kg induced massive tumor regression accompanied by suppression of intratumoral survivin.Pharmacokinetic analyses indicated that YM155 is highly distributed to tumors and at concentrations f20-fold higher than those in plasma. Theoretical analysis:YM155 M.Wt: 443.29 Formula: C20H19BrN4O3 Solubility: DMSO Purity: >99% CAS No: 781661-94-7 Storage: at -20C 2 years Availability and price: We offer significant discount for larger quantity order. For quotation, question, and order, please send email to :orders@chemremblock.com Quality control data: Quality Control by H-NMR,C-NMR,LC-MS,HPLC. Product will be shipped with supporting analytical data. Fast delivery about 4-5 working days |
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