Chemren Bio-Engineering Co., Ltd.

Product name : YM155
Item : CR1009
CAS : 781661-94-7
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Details:
Description of:YM155
YM155, a novel small molecule survivin inhibitor, suppressed expression of survivin and induced apoptosis in PC-3 and PPC-1 human HRPC cell lines at 10 nmol/L. In a s.c.xenogr afted PC-3 tumor model in mice, 3-day continuous infusions of YM155 at 3 to 10 mg/kg induced massive tumor regression accompanied by suppression of intratumoral survivin.Pharmacokinetic analyses indicated that YM155 is highly distributed to tumors and at concentrations f20-fold higher than those in plasma.

Theoretical analysis:YM155
M.Wt: 443.29
Formula: C20H19BrN4O3
Solubility: DMSO
Purity: >99%
CAS No: 781661-94-7
Storage: at -20C 2 years

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Quality control data:
Quality Control by H-NMR,C-NMR,LC-MS,HPLC.
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