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Product name : PD168393
Item : CR1824
CAS : 194423-15-9
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Details:
Biological Activity

PD168393 is an irreversible EGFR inhibitor with IC50 of 0.70 nM, irreversibly alkylate Cys-773; inactive against insulin, PDGFR, FGFR and PKC.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

 
Chemical Information
Molecular Weight 369.22
Formula C17H13BrN4O
CAS Number 194423-15-9
Purity >98%
Solubility DMSO 60 mg/mL
Storage at -20°C
Chemical Name 2-Propenamide, N-[4-[(3-bromophenyl)amino]-6-quinazolinyl]-

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