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Product name : Apremilast
Item : CR1404
CAS : 608141-41-9
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Details:

Biological Activity of Apremilast

Apremilast(CC10004) is a novel small molecule inhibitor of PDE4 with an IC50 value of 74 nM.
IC50 value: 74 nM
Target: PDE 4
Apremilast has profound anti-inflammatory properties in animal models of inflammatory disease, as well as human chronic inflammatory diseases such as psoriasis and psoriatic arthritis. Apremilast blocks the synthesis of several pro-inflammatory cytokines and chemokines, such as tumor necrosis factor alpha, interleukin 23, CXCL9, and CXCL10 in multiple cell types. As this novel PDE4 inhibitor interferes with several key processes of inflammation, Apremilast may emerge as a promising new drug for the treatment of chronic inflammatory diseases such as those of the skin and the joints.

Protocol (Extracted from published papers and Only for reference)

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Chemical Information

M.Wt 460.5 Storage Please store the product under the recommended conditions in the Certificate of Analysis.
Formula C22H24N2O7S
CAS No 608141-41-9
Solvent & Solubility

in DMSO > 10 mM

Preparing Stock Solutions

1 mg 5 mg 10 mg
1 mM 2.1716 mL 10.8578 mL 21.7155 mL
5 mM 0.4343 mL 2.1716 mL 4.3431 mL
10 mM 0.2172 mL 1.0858 mL 2.1716 mL

Clinical Information of Apremilast

Product Name Sponsor Only Condition Start Date End Date Phase Last Change Date
Apremilast Celgene Corp Psoriasis 30-NOV-10 31-DEC-16 Phase 3 01-SEP-13
Celgene Corp Psoriasis 30-SEP-12 31-AUG-15 Phase 3 31-OCT-13
Celgene Corp Ankylosing spondylitis 31-MAY-12 31-DEC-18 Phase 3 02-NOV-13
Celgene Corp Psoriatic arthritis 30-NOV-10 31-MAR-14 Phase 3 05-NOV-13
Celgene Corp Psoriatic arthritis 31-AUG-13 31-JAN-17 Phase 3 15-OCT-13

References on Apremilast


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