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Product name : Blonanserin
Item : CR1331
CAS : 132810-10-7
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Details:

Biological Activity of Blonanserin

Blonanserin(AD-5423) is a D2/5-HT2 receptor antagonist, atypical antipsychotic.
Target: D2 receptor; 5-HT2 receptor
Blonanserin(AD-5423) is a relatively new atypical antipsychotic for the treatment of schizophrenia. Blonanserin belongs to a series of 4-phenyl-2-(1-piperazinyl)pyridines and acts as an antagonist at dopamine D2, D3, and serotonin 5-HT2A receptors. Blonanserin has low affinity for 5-HT2C, adrenergic α1, histamine H1, and muscarinic M1 receptors, but displays relatively high affinity for 5-HT6 receptors [1]. AD-5423 bound preferentially to dopamine (DA)-D2 (Ki, 14.8 nM; cf. haloperidol, 8.79 nM; and clozapine, 149 nM) and serotonin (5-HT)-S2 (Ki, 3.98 nM; cf. haloperidol, 26.8 nM; and clozapine, 8.66 nM) receptors. It displayed low affinity for adrenaline (Ad)-alpha-1 (Ki, 56.3 nM) receptors and was virtually devoid of binding to DA-D1 (Ki, 2870 nM), 5-HT-S3, Ad-alpha-2, Ad-beta, muscarine, tau-aminobutyric acid and benzodiazepine receptors. In addition, AD-5423 was only a weak inhibitor of DA, 5-HT and noradrenaline uptake systems. AD-5423 (0.2-2 mg/kg p.o.) decreased exploratory activity in mice. AD-5423 (10 mg/kg p.o.), unlike haloperidol, did not antagonize SKF38393-induced vacuous oral movements in rats. Head twitches induced by 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane in mice and by para-chloroamphetamine in rats were antagonized by AD-5423 at much lower doses (0.5-2 mg/kg p.o.) than those of haloperidol and clozapine [2].
 

Chemical Information

M.Wt 367.5 Storage Please store the product under the recommended conditions in the Certificate of Analysis.
Formula C23H30FN3
CAS No 132810-10-7
Solvent & Solubility

DMSO <1 mg/mL; Water <1 mg/mL

Preparing Stock Solutions

1 mg 5 mg 10 mg
1 mM 2.7211 mL 13.6054 mL 27.2109 mL
5 mM 0.5442 mL 2.7211 mL 5.4422 mL
10 mM 0.2721 mL 1.3605 mL 2.7211 mL

References on Blonanserin

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