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Antibody-drug Conjugate/ADC Related
AMPK
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Product name : GDC-0980(RG7422)
Item : CR1095
CAS : 1032754-93-0
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| Details: |
Description of:GDC-0980(RG7422)
GDC-0980 (RG7422) prevents mTOR with a Ki of 17 nM. GDC-0980 (RG7422) is highly selective versus a large panel of kinases including others in the PIKK family. GDC-0980 (RG7422) possesses robust activity and excellent pharmacokinetic and pharmaceutical properties in cancer models driven by the PI3K pathway. GDC-0980 potently prevents signal transduction downstream of both PI3K and mTOR, as measured by pharmacodynamic (PD) biomarkers, thereby acting upon two key pathway nodes to produce the strongest attainable inhibition of signaling in the pathway. Correspondingly, GDC-0980 (RG7422) was potent across a broad panel of cancer cell lines, with the greatest potency in breast, prostate, and lung cancers and less activity in melanoma and pancreatic cancers, consistent with KRAS and BRAF acting as resistance markers. Theoretical analysis:GDC-0980(RG7422) M.Wt: 498.6 Formula: C23H30N8O3S Solubility: Unknown Purity: >99% Storage: at -20℃ 2 years CAS No: 1032754-93-0 Availability and price:GDC-0980(RG7422) Pakage：10mg/25mg/100mg/250mg/500mg/1g/5g Stock : in stock We offer significant discount for larger quantity order. For quotation, question, and order, please send email to : sales@chemrenpharm.com Quality control data: Quality Control by H-NMR,C-NMR,LC-MS,HPLC. Product will be shipped with supporting analytical data. Fast delivery about 4-5 working days |
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