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Product name : PF 03716556
Item : CR2028
CAS : 928774-43-0
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Details:

Biological Activity of PF 03716556

PF 03716556 is a potent, and selective acid pump (H+,K+ ATPase)antagonist, with pIC50 value of 6.009.
IC50 value:6.009 (pIC50)
Target: H+,K+ ATPase
PF-03716556 inhibited the activity of H+, K+-ATPase with pIC50 of 6.026 ± 0.112, 6.038 ± 0.039 and 6.009 ± 0.209 at pH 6.4 for porcine, canine and human ion-leaky membrane vesicles, respectively. PF-03716556 (PF03716556) is useful for treatment of gastroesophageal reflux disease.

Chemical Information

M.Wt 394.48 Storage Please store the product under the recommended conditions in the Certificate of Analysis.
Formula C22H26N4O3
CAS No 928774-43-0
Solvent & Solubility

DMSO

Preparing Stock Solutions

1 mg 5 mg 10 mg
1 mM 2.5350 mL 12.6749 mL 25.3498 mL
5 mM 0.5070 mL 2.5350 mL 5.0700 mL
10 mM 0.2535 mL 1.2675 mL 2.5350 mL

Clinical Information of PF 03716556

Product Name Sponsor Only Condition Start Date End Date Phase Last Change Date
PF 03716556 CJ Corp   30-NOV-11   Phase 1 20-AUG-13
CJ Corp   31-JAN-13 28-FEB-13 Phase 1 12-SEP-13

References on PF 03716556

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