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Products > Others > > PF 03716556

Product name : PF 03716556

Item : CR2028

CAS : 928774-43-0

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Details:

Biological Activity of PF 03716556

PF 03716556 is a potent, and selective acid pump (H+,K+ ATPase)antagonist, with pIC50 value of 6.009.
IC50 value:6.009 (pIC50)
Target: H+,K+ ATPase
PF-03716556 inhibited the activity of H+, K+-ATPase with pIC50 of 6.026 ± 0.112, 6.038 ± 0.039 and 6.009 ± 0.209 at pH 6.4 for porcine, canine and human ion-leaky membrane vesicles, respectively. PF-03716556 (PF03716556) is useful for treatment of gastroesophageal reflux disease.

Chemical Information

M.Wt	394.48	Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Formula	C22H26N4O3
CAS No	928774-43-0
Solvent & Solubility	DMSO

Preparing Stock Solutions

	1 mg	5 mg	10 mg
1 mM	2.5350 mL	12.6749 mL	25.3498 mL
5 mM	0.5070 mL	2.5350 mL	5.0700 mL
10 mM	0.2535 mL	1.2675 mL	2.5350 mL

Clinical Information of PF 03716556

Product Name	Sponsor Only	Condition	Start Date	End Date	Phase	Last Change Date
PF 03716556	CJ Corp		30-NOV-11		Phase 1	20-AUG-13
PF 03716556	CJ Corp		31-JAN-13	28-FEB-13	Phase 1	12-SEP-13

References on PF 03716556

[1]. Mori et al (2009) N-(2-hydroxyethyl)-N,2-dimethyl-8-{[(4R)-5-methyl-3,4-dihydro-2H-chromen-4-yl]amino}imidazo[1,2-a]py ridine-6-carboxamide (PF-03716556), a novel, potent, and selective acid pump antagonist for the treatment of gastroesophageal reflux disease

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