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Product name : Remodelin
Item : CR2015
CAS : 949912-58-7
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Details:

Biological Activity of Remodelin

Remodelin is a novel potent and selective inhibitor of the acetyl-transferase protein NAT10.
IC50 value:
Target: NAT10 inhibitor
Remodelin can improve nuclear architecture, chromatin organization, and fitness of both human lamin A/C-depleted cells and HGPS-derived patient cells, and decrease markers of DNA damage in these cells. Using a combination of chemical, cellular, and genetic approaches, acetyl-transferase protein NAT10 was identified as the target of Remodelin that mediated nuclear shape rescue in laminopathic cells via microtubule reorganization. Down-regulation and mutations of the nuclear-architecture proteins lamin A and C cause misshapen nuclei and altered chromatin organization associated with cancer and laminopathies, including the premature-aging disease Hutchinson-Gilford progeria syndrome (HGPS). Remodelin is a useful chemical tool to study how NAT10 affects nuclear architecture and suggest alternative strategies for treating laminopathies and aging.

Chemical Information

M.Wt 282.36 Storage Please store the product under the recommended conditions in the Certificate of Analysis.
Formula C15H14N4S
CAS No 949912-58-7
Solvent & Solubility

100 mM in DMSO

Preparing Stock Solutions

1 mg 5 mg 10 mg
1 mM 3.5416 mL 17.7079 mL 35.4158 mL
5 mM 0.7083 mL 3.5416 mL 7.0832 mL
10 mM 0.3542 mL 1.7708 mL 3.5416 mL

References on Remodelin

Availability and price:
Stock : in stock
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