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Product name : Vidofludimus
Item : CR2013
CAS : 717824-30-1
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Details:

Biological Activity of Vidofludimus

Vidofludimus(4SC-101; SC12267) is a novel immunosuppressive drug that inhibits DHODH; inhibits IL-17 secretion in vitro independently of effects on lymphocyte proliferation.
IC50 value:
Target: DHODH inhibitor
in vitro: 4SC-101 is a potent inhibitor of human DHODH, inhibits lymphocyte proliferation, and uniquely blocks phytohemagglutinin-stimulated IL-17 production by lymphocytes [2].
in vivo: In vivo Vido treatment alone most effectively reduced macroscopic and histological pathology and the numbers of CD3+ T cells. In contrast, similarly reduced nuclear signal transducer and activator of transcription 3 (STAT3) binding and IL-17 levels were observed from animals treated with Vido alone and Vido + Uri. Vido improves TNBS-induced colonic inflammation by a unique dual mode of action [1]. Oral administration of 4SC-101 effectively improved both chronic DSS and acute TNBS colitis in mice. In these colitis models the overall efficacy profile of 4SC-101 was similar to that of dexamethasone [2].

Chemical Information

M.Wt 355.36 Storage Please store the product under the recommended conditions in the Certificate of Analysis.
Formula C20H18FNO4
CAS No 717824-30-1
Solvent & Solubility

DMSO 49 mg/ml

Preparing Stock Solutions

1 mg 5 mg 10 mg
1 mM 2.8140 mL 14.0702 mL 28.1405 mL
5 mM 0.5628 mL 2.8140 mL 5.6281 mL
10 mM 0.2814 mL 1.4070 mL 2.8140 mL

References on Vidofludimus

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