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Product name : Monomethyl auristatin E
Item : CR2011
CAS : 474645-27-7
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Details: |
Monomethyl auristatin E (MMAE) is a hot topic in Antibody-drug conjugates (ADCs) studies. It is an antimitotic agent which inhibits cell division by blocking the polymerisation of tubulin.
IC50 Value: N/A Target: ADCs cytotoxin; Microtubule/Tubulin For example VcMMAE, an antibody-drug conjugate (ADC) with potent antitumor activity by using the anti-mitotic agent, monomethyl auristatin E (MMAE), linked via the lysosomally cleavable dipeptide, valine-citrulline (vc). Antibody-drug conjugates (ADCs) are designed to combine the exquisite specificity of antibodies to target tumor antigens with the cytotoxic potency of chemotherapeutic drugs. In vivo studies demonstrated that the peptide-linked conjugates induced regressions and cures of established tumor xenografts with therapeutic indices as high as 60-fold. These conjugates illustrate the importance of linker technology, drug potency and conjugation methodology in developing safe and efficacious mAb-drug conjugates for cancer therapy. Availability and price: Stock : in stock We offer significant discount for larger quantity order. For quotation, question, and order, please send email to :sales@chemrenpharm.com |
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