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产品 > MAPK > B-Raf > GDC-0879
产品名称 : GDC-0879
型号 : CR1057
CAS : 905281-76-7
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产品详细:

Description of:GDC-0879
GDC-0879 is a highly selective, novel potent, orally bioavailable B-Raf inhibitor in various in vitro and cell-based assays with an IC50 estimate of 0.13 nM against purified B-Raf V600E enzyme and a cellular pERK IC50 of 63 nM in the MALME-3M cell line.For this compound, subnanomolar enzyme potency translated into very effective reduction of cellular viability of BRAF-mutant Malme3M cells (EC50 values were 0.75 umol/L for GDC-0879).In GDC-0879-treated mice, both cell line- and patient-derived BRAFV600E tumors exhibited stronger and more sustained pharmacodynamic inhibition (>90% for 8 hours) and improved survival compared with mutant KRAS-expressing tumors.


Theoretical analysis:GDC-0879
M.Wt: 334.37
Formula: C19H18N4O2
Solubility: Unknown
Purity: >99%
Storage: -20C 2 years
Appearance:off-white solid
CAS No: 905281-76-7

Availability and price:
Pakage:250mg/500mg/1g/5g
We offer significant discount for larger quantity order.
For quotation, question, and order, please send email to :
orders@chemrenblock.com
Quality control data:
Quality Control by H-NMR,C-NMR,LC-MS,HPLC.
Product will be shipped with supporting analytical data.
Fast delivery about 4-5 working days

 


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