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产品 > MAPK > B-Raf > Sorafenib Tosylate(甲磺酸索拉非尼)
产品名称 : Sorafenib Tosylate(甲磺酸索拉非尼)
型号 : CR1056
CAS : 475207-59-1
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产品详细:

Description of:Sorafenib Tosylate(甲磺酸索拉非尼)
Sorafenib (Bay 43-9006) is a novel bi-aryl urea compound that inhibits cell proliferation by targeting the ERK pathway and angiogenesis by targeting the receptor tyrosine kinases VEGFR-2 and PDGFR-ß and their associated signaling cascades. Although sorafenib was initially developed as a Raf kinase inhibitor (IC50 = 6 nM), it has since been shown to have activity against many receptor tyrosine kinases involved in tumorigenesis and angiogenesis including FGFR-1, wt BRAF and V599E mutant BRAF, as well as members of the so-called "split kinase" family: VEGFR-2, VEGFR-3, PDGFR-ß, c-KIT, and Flt3. However,sorafenib is not active against erbB1, erbB2, ERK-1, MEK-1, EGFR, HER-2, IGFR-1, c-MET, c-yes, PKB, PKA, cdk1/cyclinB, PKC, and pim-1. In cellular mechanistic assays, sorafenib decreased basal phosphorylation of the ERK pathway in melanoma, breast, colon, and pancreatic tumor cell lines.


Theoretical analysis:Sorafenib Tosylate(甲磺酸索拉非尼)
M.Wt: 637.03
Formula: C21H16ClF3N4O3.C7H8O3S
Solubility: DMSO
Purity: >99%
Storage: at -20℃ 2 years
CAS No: 475207-59-1

Availability and price:
We offer significant discount for larger quantity order.
For quotation, question, and order, please send email to : 
sales@chemrenpharm.com

Quality control data:
Quality Control by H-NMR,C-NMR,LC-MS,HPLC.
Product will be shipped with supporting analytical data.
Fast delivery about 4-5 working days

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注意事项:仅供科学研究和实验室使用。


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