常州市存仁生物工程有限公司

产品名称 : AV-951(Tivozanib)
型号 : CR1228
CAS : 475108-18-0
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产品详细:
Description of:AV-951(Tivozanib)
AV-951 (Tivozanib) is a novel quinoline-urea derivative and now developed by AVEO. AV-951 also inhibits phosphorylation of PDGFRß and c-Kit with IC50 of 1.72nm and 1.63nM, AV-951 (Tivozanib) will block VEGF-dependent activation of mitogen-activated protein kinases and proliferation of endothelial cells. In vivo studies show that AV-951 also decreases the micro vessel density and suppresses VEGFR-2 phosphorylation levels in tumor xenografts, especially at a concentration of 1mg/kg (p.o. administration). AV-951 (Tivozanib) shows almost complete inhibition of tumor xenografts growth (TGI>85%) in athymic rats. 

Theoretical analysis:AV-951(Tivozanib)
M.Wt: 454.86
Formula: C22H19ClN4O5
Solubility: DMSO
Purity: >99%
Storage: at -20℃ 2 years
CAS No: 475108-18-0

Availability and price:AV-951(Tivozanib)
Pakage:25mg/50mg/100mg/250mg/500mg/1g/5g
Stock : in stock
We offer significant discount for larger quantity order.
For quotation, question, and order, please send email to : sales@chemrenpharm.com

Quality control data:
Quality Control by H-NMR,C-NMR,LC-MS,HPLC.
Product will be shipped with supporting analytical data.
Fast delivery about 4-5 working days


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