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产品 > HDAC > HDAC > SB939
产品名称 : SB939
型号 : CR1133
CAS : 929016-96-6
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产品详细:
Description of:SB939
SB939 is a new hydroxamic acid based histone deacetylase inhibitor with IC50 of 0.48 μM for HCT-116 colon cancer cell line and 70 nM for HL-60 acute myeloid leukemia cell line. In vitro, SB939 inhibits class I, II, and IV HDACs, with no effects on other zinc binding enzymes, and shows significant antiproliferative activity against a wide variety of tumor cell lines. It has very favorable pharmacokinetic properties after oral dosing in mice, with >4-fold increased bioavailability and 3.3-fold increased half-life over suberoylanilide hydroxamic acid (SAHA). In contrast to SAHA, SB939 accumulates in tumor tissue and induces a sustained inhibition of histone acetylation in tumor tissue. 

Theoretical analysis:SB939
M.Wt: 358.48
 Formula: C20H30N4O2
Solubility: Unknown
Purity: >99%
Storage: at -20
CAS No: 929016-96-6

Availability and price:SB939
Pakage:10mg/25mg/100mg/250mg/500mg/1g/5g
Stock : in stock
We offer significant discount for larger quantity order.
For quotation, question, and order, please send email to :
orders@chemrenblock.com

Quality control data:
Quality Control by H-NMR,C-NMR,LC-MS,HPLC.
Product will be shipped with supporting analytical data.
Fast delivery about 4-5 working days


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