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产品 > 抑制剂 > > Monomethyl auristatin E
产品名称 : Monomethyl auristatin E
型号 : CR2011
CAS : 474645-27-7
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产品详细:

Monomethyl auristatin E的生物活性

 

Monomethyl auristatin E (MMAE) is a hot topic in Antibody-drug conjugates (ADCs) studies. It is an antimitotic agent which inhibits cell division by blocking the polymerisation of tubulin. 
IC50 Value: N/A
Target:  ADCs cytotoxin; Microtubule/Tubulin
For example VcMMAE, an antibody-drug conjugate (ADC) with potent antitumor activity by using the anti-mitotic agent, monomethyl auristatin E (MMAE), linked via the lysosomally cleavable dipeptide, valine-citrulline (vc). Antibody-drug conjugates (ADCs) are designed to combine the exquisite specificity of antibodies to target tumor antigens with the cytotoxic potency of chemotherapeutic drugs. In vivo studies demonstrated that the peptide-linked conjugates induced regressions and cures of established tumor xenografts with therapeutic indices as high as 60-fold. These conjugates illustrate the importance of linker technology, drug potency and conjugation methodology in developing safe and efficacious mAb-drug conjugates for cancer therapy.
 


分子量 717.98 储存条件 参考CoA中推荐的条件进行储存。
分子式 C39H67N5O7
CAS号 474645-27-7
溶剂/溶解度 DMSO > 100 mg/ml

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